The knockout stages for the 2020-21 Total CAF Champions League will kickoff with the Quarterfinals taking place starting 14 May 2021.
Here are the Quarterfinal fixtures (in GMT)

First Leg

Friday 14 May 2021

19:00 Algiers MC Alger (Algeria) – Wydad (Morocco)

Saturday 15 May 2021

16:00 Algiers CR Belouizdad (Algeria) – Esperance (Tunisia)

16:00 Johannesburg Kaizer Chiefs (South Africa) – Simba (Tanzania)

19:00 Cairo Al Ahly (Egypt) – Mamelodi Sundowns (South Africa)

Second Leg

Saturday 22 May 2021

13:00 Tshwane Mamelodi Sudowns (South Africa) – Al Ahly (Egypt)

13:00 Dar es Salaam Simba (Tanzania) – Kaizer Chiefs (South Africa)

16:00 Casablanca Wydad (Morocco) – MC Alger (Algeria)

16:00 Tunis Esperance (Tunisia) – CR Belouizdad (Algeria)